To guide us through this process, we enlisted the expertise of Registered Dietitian Katie Drakeford to help identify critical ingredients and strategies for finding the right muscle-building supplements for you. Our buying guide covers everything you need to know, from protein powders to creatine, so you can make informed choices and maximize your gains. We will also introduce a lineup of top-selling products from sites like Amazon that will fit your needs.
Quick List - Top Supplements to Gain Muscle
GNC PRO PERFORMANCE®
Balanced Protein and Carbohydrate Blend for Muscle Gain
Katie Drakeford, MA, RD, CSP, LD, CLC, is a Registered Dietitian with over 12 years of experience serving all ages across the lifespan, from critically ill neonates to aging populations. She holds a board certification in pediatric nutrition and serves as a subject matter expert on the Academy of Nutrition and Dietetics pediatric exam committee. She attended the University of Oklahoma Health Sciences Center, where she received a Master’s in Dietetics and completed her Dietetic Internship.
mybest US' editing team consists of experienced members who have backgrounds in writing, editing, translation, and more. We are dedicated to researching what makes a product or service the best to users in the US in order to create top-quality articles. From skincare, to kitchen appliances, and to DIY supplies, our mission is to find the best ones for you.
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Table of Contents
These supplements often have nutrients and other compounds that may support muscle hypertrophy, along with proper diet and exercise.
Muscle-building supplements are products designed to enhance muscle growth and strength and can significantly benefit your fitness regimen. They are frequently used with resistance training and a nutritious diet to maximize muscle hypertrophy, the process through which muscles grow in size and strength. These products often contain vital ingredients like protein, creatine, and amino acids, essential for muscle repair and growth.
Using these supplements with a well-rounded exercise program can help you achieve more significant muscle strength and endurance gains. However, it's important to choose supplements based on your specific fitness goals and ensure they complement your diet and training routine.
Many muscle building supplements appear safe at standard doses, but some users still experience negative side effects.
Before starting any new supplement regimen, it is critical to consult with a healthcare provider. This step ensures that the supplements will help you achieve your muscle growth goals and maintain overall health. A medical professional can provide personalized advice based on your health history and current conditions.
This guidance is crucial because some supplements can interact with medications or be unsuitable due to pre-existing health conditions. Always ensure that your pursuit of fitness through supplements is aligned with your overall health priorities.
Like our fitness goals, supplements to gain muscle come in many varieties. Here are a few key points to consider when choosing the right muscle-building supplement for you.
Since supplements are not FDA-regulated, this is one measure you can take to ensure you get exactly what the label says.
Verifying third-party certification is a crucial step when selecting a muscle-building supplement. Organizations such as NSF International or Informed Sport offer independent testing that reassures consumers about supplements' purity, safety, and effectiveness. Products certified by these bodies are tested for harmful substances, such as unsafe levels of heavy metals and banned substances, and verified to contain the ingredients listed on their labels at the declared potencies.
This certification can give you peace of mind that the supplement you choose adheres to strict quality standards and is free from banned or harmful substances. Selecting products with these certifications may help you avoid health risks and ensure the supplements effectively support your muscle growth goals.
Selecting the right supplements requires understanding their ingredients and how they align with your fitness goals.
Creatine monohydrate may be effective for muscle growth in young, healthy populations with adequate training.
Creatine monohydrate is renowned for its ability to enhance muscle strength and size. This supplement works by increasing the availability of creatine and phosphocreatine in the muscle, aiding in energy maintenance during high-intensity training and improving overall performance. This can lead to more effective workouts and, over time, significant gains in muscle mass.
Choosing a supplement with a high concentration of creatine monohydrate can be particularly beneficial for those aiming to enhance their muscle strength significantly. Creatine's proven track record of supporting muscle growth makes it a top pick for athletes and fitness enthusiasts.
Beta-alanine may be effective for improving high-intensity exercise performance when taken long-term.
Beta-alanine is a popular ingredient in many pre-workout supplements because studies show it may help delay fatigue and improve overall workout performance. It achieves this by increasing muscle carnosine levels, which counteract lactic acid buildup during intense exercise. This can allow for longer and more intense training sessions, which are crucial for muscle growth.
Opting for a supplement that includes beta-alanine can be particularly effective for those looking to extend their workout capacity and enhance muscle gains. It is beneficial for both short bursts of activity and longer-duration exercises, providing a versatile boost to various workout regimes.
HMB is effective in increasing muscle strength in elderly populations by promoting muscle protein synthesis and limiting muscle wasting.
Maintaining muscle mass is crucial for physical strength, overall health, and mobility for older adults. Getting adequate amounts of protein and weight-bearing exercise is vital for maintaining muscle mass in aging populations. Supplements containing HMB (Beta-Hydroxy Beta-Methylbutyrate) or high-quality whey protein can be beneficial. Studies show that HMB helps slow muscle protein breakdown and can be crucial for long-term muscle maintenance, while whey protein may improve muscle mass and function in elderly populations when taken in conjunction with resistance training exercises.
When choosing supplements to combat age-related muscle loss, look for ones that are easy to consume and digest. Products designed for older adults should avoid excessive stimulants and instead focus on supporting sustainable muscle health and recovery. These supplements can significantly aid in prolonging physical independence and enhancing quality of life as one ages.
Ready-to-drink supplements are usually smoother, making them more palatable for some.
Convenience can significantly influence adherence to a fitness regimen. Ready-to-drink supplements or individual packets are great options for those on the go or who don't want to fuss with measuring out the appropriate dose. These options eliminate the need for measuring scoops and mixing powders, offering a quick and easy solution to support workout needs.
Such formats are handy for maintaining a consistent supplement intake. They ensure you get the necessary nutrients to support muscle growth without the hassle of traditional powder supplements. This convenience can make staying committed to your fitness goals more manageable, even on the busiest days.
Dairy allergies are a major concern as many protein products are made from cow's milk protein.
Finding suitable supplements is paramount for individuals with dietary restrictions or allergies. Luckily, there are lots of companies that make plant-based protein supplements, too. Plant-based proteins like pea, hemp, or rice are excellent alternatives to traditional dairy-based supplements like whey. These options provide essential amino acids necessary for muscle repair and growth without the allergens that can cause adverse reactions.
When choosing a supplement, it is crucial to select one that does not compromise your dietary principles or health needs. Read the label carefully, and if there's an ingredient you don't recognize, look it up before purchasing to ensure you meet your dietary preferences and needs. Plant-based and allergen-free options ensure that you meet your protein requirements and align with broader health and lifestyle choices, providing peace of mind and muscle-building benefits.
Products | Image | Click to purchase | Key features | Details | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Third-Party Certification | Creatine Monohydrate | Beta-Alanine | HMB/Whey Protein | Form | Plant-Based | Volume | |||||
1 | Optimum Nutrition Serious Mass | ![]() | High-Calorie Supplement With Creatine for Muscle Growth | Whey Protein | Powder | 6 lb. | |||||
2 | GNC PRO PERFORMANCE® Weight Gainer - Strawberries and Cream | ![]() | Balanced Protein and Carbohydrate Blend for Muscle Gain | Whey Protein | Powder | 2.42 lb. | |||||
3 | MuscleTech Platinum Musclebuilder | ![]() | Clinically-Backed Supplement for Enhanced Muscle Performance | × | Capsule | 30 Capsules | |||||
4 | NATURADE Weight Gain - Vanilla | ![]() | Nutrient-Dense Formula for Calorie Boost and Weight Gain | Whey Protein | Powder | 2.5 lb. | |||||
5 | Naked Nutrition Chocolate Weight Gainer Protein Supplement | ![]() | High-Calorie, Clean Protein for Muscle Gain | Whey Protein | Powder | 8 lb. | |||||
6 | Vega Sport® Premium Vega Sport® Premium|Plant-Based Protein Powder|Vanilla | ![]() | Plant-Based Protein for Post-Workout Recovery | unknown | Powder | 29.2 oz | |||||
7 | BSN TRUE MASS | ![]() | High-Calorie Mass Gainer for Muscle Growth | Whey Protein | Powder | 5.82 lb. | |||||
8 | Amazing Muscle Whey Protein Gainer | ![]() | High-Protein Supplement for Lean Muscle Gain | Whey Protein | Powder | 6 lb. | |||||
9 | GNC PRO PERFORMANCE® GNC PRO PERFORMANCE|Beta-Alanine 3200mg|120 Caplets (30 Servings) | ![]() | Beta-Alanine Tablets for Enhanced Muscle Performance | unknown | Ready-to-Drink (Capsules) | 120 Caplets (30 Servings) | |||||
10 | Genuine Muscle Milk© Genuine|Ready-to-Drink Supplement |Chocolate | ![]() | Convenient Ready-to-Drink Protein Shake for On-the-Go Nutrition | unknown | Ready-to-Drink | 11 fl oz. |
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
Serious Mass is designed for those looking to gain muscle and weight effectively. With 1,250 calories and 50 grams of protein per serving, it provides the necessary nutrients to support muscle building and recovery. Each serving also includes 252-254 grams of carbohydrates to fuel workouts and three grams of creatine monohydrate to maximize muscle growth. The inclusion of 25 vitamins and essential minerals enhances overall health, making it a comprehensive supplement for weight gain and muscle development.
To use, blend two scoops with 24 fluid ounces of cold water or milk, optionally adding fruits, peanut butter, or other calorie-dense foods. For beginners, starting with a one-scoop serving is recommended. This supplement can be taken post-workout or between meals to add essential calories, carbs, and protein to your diet.
Volume | 6 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
Volume | 2.42 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | × |
Volume | 30 Capsules |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
Naturade Weight Gain is designed for individuals looking to increase their calorie intake and gain weight effectively. Each serving provides 24 grams of carbohydrates and 10 grams of protein, enhancing overall caloric absorption. The formula contains natural enzymes like papain, bromelain, and pancreatin to optimize nutrient utilization, making it an efficient addition to your diet.
This stimulant- and steroid-free product can be easily incorporated into your routine. Blend two scoops with eight ounces of water or whole milk for a quick nutritional boost, or use four scoops with sixteen ounces of milk for additional calories. For best results, consume one shake before noon and another an hour before bedtime. Naturade Weight Gain is free from aspartame, added sugar, artificial sweeteners, flavors, colors, preservatives, and MSG, ensuring a clean and natural option for weight gain.
Volume | 2.5 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
Naked Double Chocolate Mass offers a potent blend of whey and micellar casein proteins combined with organic tapioca maltodextrin and organic coconut sugar. Each serving delivers 1,360 calories, 50 grams of protein, and 261 grams of complex carbohydrates, making it ideal for those seeking to increase their caloric intake and build muscle. This gluten-free, GMO-free, and soy-free formula contains no artificial additives, ensuring a clean source of nutrition.
The combination of fast-absorbing whey and slow-digesting casein provides a sustained release of amino acids to support muscle synthesis throughout the day. This makes Naked Double Chocolate Mass suitable for pre- and post-workout nutrition and for making calorie-rich smoothies and recipes. Natural ingredients like organic cacao and sea salt enhance the flavor without compromising quality or health. This supplement is designed for anyone looking to gain weight and muscle mass healthily, regardless of their workout routine.
Volume | 8 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | unknown |
Vega Sport Premium Protein Powder offers 30 grams of plant-based protein, five grams of BCAAs, and two billion CFUs of probiotics per serving to aid muscle recovery and digestive health. This NSF Certified for Sport product is free of banned substances, gluten, and artificial additives, making it a clean choice for athletes.
Sweetened with stevia and containing no added sugars, it fits nicely into keto diets. While some users have mixed feelings about the taste and texture, it blends well with water or non-dairy beverages for a smooth post-workout shake. Always check allergen warnings due to shared manufacturing facilities.
Volume | 29.2 oz |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
TRUE-MASS® is designed for athletes needing above-normal caloric intake for muscle building and recovery. Each serving delivers 700-710 calories, with a 2:1 ratio of carbohydrates (85-90 grams) to protein (46-50 grams). The blend includes multiple protein sources and medium-chain triglycerides (MCTs) for a well-rounded nutritional profile.
This mass gainer supports recovery from intense training and is ideal post-workout, between meals, or before bed. It features BSN's renowned flavor technology for a milkshake-like experience. While many users appreciate the taste and performance benefits, some report stomach discomfort. The product contains allergens such as milk, egg, wheat, and soy and is manufactured in a facility that processes various other allergens.
Volume | 5.82 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | Whey Protein |
Amazing Muscle Whey Protein Gainer supports muscle growth and workout recovery with 1,250 nutrient-rich calories and 50 grams of protein per serving. This strawberry-flavored supplement mixes into shakes, offering a delicious way to enhance your nutritional intake. Made in the USA under strict GMP compliance, it contains no banned substances. The product includes essential vitamins and minerals to support overall health and muscle development, making it a comprehensive option for those looking to increase muscle mass effectively.
While many users appreciate the easy mixing and significant protein content, some have reported issues with the taste and product quality, including occasional clumping and an off-putting aftertaste. Overall, Amazing Muscle Whey Protein Gainer is a robust choice for those seeking to enhance their muscle mass and caloric intake in a convenient and flavorful way.
Volume | 6 lb. |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | unknown |
GNC Pro Performance Beta-Alanine tablets deliver 3,200mg of clinically studied beta-alanine per serving, designed to support muscle function and reduce fatigue. By boosting muscle carnosine levels, this supplement acts as an efficient muscle pH buffer, which helps control muscle fatigue during intense workouts. This makes it a valuable addition to the regimen of athletes and fitness enthusiasts looking to improve their performance and endurance.
Some users report experiencing a tingling sensation in their arms, a common side effect of beta-alanine. Despite this, many customers appreciate these tablets' performance and stamina benefits. As with all supplements, the statements made about this product have not been evaluated by the FDA, and it is not intended to diagnose, treat, cure, or prevent any disease.
Volume | 120 Caplets (30 Servings) |
---|
Third-Party Certification | |
---|---|
Creatine Monohydrate | |
Beta-Alanine | |
HMB/Whey Protein | unknown |
MUSCLE MILK GENUINE Protein Shake offers the convenience of a ready-to-drink format, eliminating the need to measure and mix powders. Each 11-ounce serving provides 25 grams of high-quality protein derived from milk, helping to rebuild muscles after exercise. This shake is also an excellent source of calcium, fiber, and vitamins A and D, with zero sugar, making it a nutritious choice for pre-workout, post-workout, or meal replacement.
Designed to fuel recovery and enhance physical performance, this protein shake supports various fitness goals while being easy to consume on the go. Despite its nutritional benefits, some users have reported an undesirable chalky taste that sticks to the tongue.
Volume | 11 fl oz. |
---|
No. 1: Optimum Nutrition|Serious Mass
No. 2: GNC PRO PERFORMANCE®|Weight Gainer - Strawberries and Cream
No. 3: MuscleTech|Platinum Musclebuilder
No. 4: NATURADE|Weight Gain - Vanilla
No. 5: Naked Nutrition|Chocolate Weight Gainer Protein Supplement
View Full RankingThe descriptions of each product are referenced from content available on manufacturer, brand, and e-commerce sites.
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