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Digestive Enzyme SupplementsHelping You Find the Best
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Digestive Enzyme SupplementsHelping You Find the Best
  • 10 Best Digestive Enzyme Supplements  [Registered Dietitian-Reviewed] 1
  • 10 Best Digestive Enzyme Supplements  [Registered Dietitian-Reviewed] 2
  • 10 Best Digestive Enzyme Supplements  [Registered Dietitian-Reviewed] 3
  • 10 Best Digestive Enzyme Supplements  [Registered Dietitian-Reviewed] 4
  • 10 Best Digestive Enzyme Supplements  [Registered Dietitian-Reviewed] 5

10 Best Digestive Enzyme Supplements [Registered Dietitian-Reviewed]

When it comes to alleviating discomfort from food intolerances and improving overall digestive health, digestive enzyme supplements can play a pivotal role. These supplements help your body break down food components into simpler, more absorbable forms, relieving symptoms like bloating, gas, and discomfort after meals. However, with a myriad of products on the market, choosing the right supplement that fits your dietary needs can be daunting.


To provide expert guidance through this complex selection process, we've collaborated with Kathy Shattler, a Registered Dietitian Nutritionist with over 25 years of experience in various medical specialties, including supplements and digestive health. 


Our guide explores key considerations such as the variety of enzymes included, the presence of additional supportive ingredients, and more. We've carefully researched a range of best-selling digestive enzyme supplements on sites like Amazon and iHerb to ensure you find a product that not only addresses your specific digestive issues but also promotes your overall digestive health.

Last updated 05/29/2024

Quick List - Top Digestive Enzyme Supplement

1

NOW Health Group Inc.

Super Enzymes
Super Enzymes

Supercharge Your Digestion Game

2

Zenwise, LLC

Digestive Enzymes
Digestive Enzymes

Prebiotic, Probiotics, Sea Vegetable Extracts, and Fruit Powders

3

JB7, LLC

Physician's ChoiceDigestive Enzymes
Digestive Enzymes

16 Enzymes for Optimal Digestion

4

KK Nutrition, Inc.

LemmeDebloat
Debloat

Triple Action Gut Relief

5

Prestige Brands, Inc.

BeanoGas Prevention and Digestive Enzyme Supplement
Gas Prevention and Digestive Enzyme Supplement

Enjoy Meals with Less Gas

Kathy Shattler, MS, RDN
Expert
Registered Dietitian Nutritionist
Kathy Shattler, MS, RDN

A Registered Dietitian Nutritionist for over 25 years, Kathy has mastered numerous medical specialties and teaching methods: health promotion, counseling, academic teaching, endocrinology, psychiatry/mental health, supplements, diabetes, obesity, heart disease, aging, and alternative medicine. Experiences include: -Managing her own telehealth/nutrition consulting business -Directing a continuing education program for RDs and nurses -Consulting for long-term care regulatory affairs -Working with State and local health departments -Coordinating diabetes education programs Her experiences led her to reach people with life-changing information as a medical editor and writer. For over five years, Kathy has acquired increasingly complex roles. Passionate about the root causes of disease, she obtained her certification in Integrative Medicine and Functional Nutrition from the Academy of Nutrition and Dietetics three years ago. This series continues to influence her approach to writing.

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Table of Contents

What Are Digestive Enzyme Supplements?

Expert
Expert

Enzymes help by breaking food components down into the smallest particles that can be absorbed to create energy and nourish the body.

What Are Digestive Enzyme Supplements?

Digestive enzymes are crucial for breaking down food into absorbable components. They transform carbohydrates, proteins, and fats into smaller molecules such as glucose, amino acids, and fatty acids, aiding their absorption into the bloodstream. This process helps maximize the body's energy production and nutrient utilization.

What Are the Benefits?

Expert
Expert

Digestive enzyme supplements help improve digestion and relieve issues like gas, bloating, and fatigue by breaking down food more effectively.

What Are the Benefits?

For those with food intolerances, these supplements can be particularly beneficial. By aiding the breakdown of substances like lactose or fructose, enzyme supplements allow individuals to enjoy a broader range of foods without discomfort. This can significantly enhance their quality of life and dietary satisfaction.

How to Choose Digestive Enzyme Supplement

Here are the points to keep in mind when choosing the best Digestive Enzyme Supplement.

1

Consult Third Party-Testers to Ensure Quality

Expert
Expert

Look for third-party lab testing to ensure your supplement is safe and accurately labeled.

Consult Third Party-Testers to Ensure Quality

When choosing digestive enzyme supplements, verifying safety through third-party lab testing is crucial. Reputable testing organizations like NPA, USP, NSF, and Consumerslab.com are known for their rigorous standards. Identity specifications, safety and toxicity tests, and labeling accuracy are also key factors to check. These measures help safeguard against potential health risks. 

2

Tailor Your Enzyme Choice to Address Specific Food Intolerances or Digestive Concerns

Specific enzymes are designed to target and digest different types of problematic foods.

For Comprehensive Digestive Health, Choose a Blend of Multiple Enzymes

Expert
Expert

An enzyme supplement with a blend of multiple enzymes helps break down all types of foods for better digestion and nutrient absorption.

For Comprehensive Digestive Health, Choose a Blend of Multiple Enzymes

For those experiencing general bloating and gas post-meal, a blend of multiple digestive enzymes can be particularly effective. A multi-enzyme supplement targets proteins, fats, carbohydrates, and fibers with specific enzymes like protease, lipase, amylase, and cellulase. Such a blend ensures that all major food components are digested more efficiently, enhancing nutrient absorption and minimizing digestive distress.

Select Supplements for Specific Food Intolerances - Dairy Products, Fructose and Legumes

Expert
Expert

It is very important to target the problematic food with the right enzyme, like lactase for dairy or alpha-galactosidase for legumes.

Select Supplements for Specific Food Intolerances -  Dairy Products, Fructose and Legumes

Choosing the right enzyme supplement is crucial for managing food intolerances. If you have issues with dairy, fructose, or legumes, it's essential to target these specific foods. 


For those with lactose intolerance, lactase supplements can help you enjoy dairy products without discomfort. Similarly, if fructose causes issues, supplements, including aldolase, can ease your symptoms, allowing you to enjoy fruits and sugary foods.


Legumes can be problematic for some, but alpha-galactosidase supplements can help digest these foods better. By choosing supplements that include enzymes that target certain foods, you can alleviate symptoms and enjoy a more varied diet without worry.

3

Supplements With Enteric Coating May Help Prevent Related Nausea and Stomach Pain

Expert
Expert

Enteric-coated supplements can protect enzymes from stomach acid and help prevent nausea and stomach pain.

Supplements With Enteric Coating May Help Prevent Related Nausea and Stomach Pain

Enzyme supplements with enteric coating ensure that the enzymes reach the intestines before being released, preventing nausea and stomach pain. The enteric coating protects the enzymes from being destroyed by excess stomach acid or low pH. This protection is particularly beneficial for individuals who suffer from heartburn due to excess stomach acid secretion


Enteric-coated supplements maintain their effectiveness by shielding the enzymes. Those experiencing discomfort from high stomach acid levels should consider these supplements to improve digestion without causing additional stomach issues.

4

Keep in Mind the Added Ingredients of the Supplement

The extra ingredients in some supplements may affect how your body reacts to the supplements.

Avoid Added Sugars to Prevent Further Complications

Expert
Expert

Added sugars may cause complications like gas, bloating, and diarrhea.

Avoid Added Sugars to Prevent Further Complications

When selecting enzyme supplements, it's crucial to avoid those with added sugars to prevent digestive issues such as gas, bloating, and diarrhea, especially in sensitive individuals. Added sugars require extra breakdown by the body, which can strain the digestive system, leading to fatigue and, in some cases, anemia due to poor nutrient absorption. 


Carefully checking ingredient lists for hidden sugars and choosing supplements without added sugars can help maintain better digestive health and ensure the supplements work effectively without causing additional complications.

For Sensitive Stomachs, Consider Potential Side-Effects of Supplements with Added Prebiotics

Expert
Expert

Be aware that added prebiotics can cause bloating, gas, and diarrhea, especially for those with SIBO, FODMAP intolerance, or IBS

For Sensitive Stomachs, Consider Potential Side-Effects of Supplements with Added Prebiotics

Enzyme supplements with added prebiotics can further aid digestion, but they may also cause unwanted side effects like bloating, gas, and diarrhea. These symptoms occur because prebiotics have an osmotic effect in the intestines, causing rapid fermentation. Individuals with small intestinal bacterial overgrowth (SIBO), irritable bowel syndrome (IBS), or FODMAP intolerance should avoid prebiotics. Their sensitivity can result in unpleasant digestive symptoms, making it crucial to consider potential side effects before choosing supplements with added prebiotics.

5

For Vegetarian Options, Check the Label Proper Certification

Expert
Expert

Properly labeled vegetarian enzymes are as effective as animal-based ones.

For Vegetarian Options, Check the Label Proper Certification

If you are vegetarian or have a dietary restriction, it's important to look at the source of the enzyme. For those who need them, vegetarian enzyme supplements are generally as effective as animal-based ones, though metabolism may vary.


Enzymes such as protease, lipase, and amylase can be found in a variety of plant-based and natural sources. Careful selection based on labels and certifications can help maintain digestive health without compromising dietary principles.

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10 Best Digestive Enzyme Supplements Ranking

Here are the best digestive enzyme supplements from Amazon and other EC sites, ranked by us according to our buying guide criteria.
Popularity
Filter
Products
Image
Click to purchase
Key features
Details
Unit Count
Unit Form
Number of Enzymes
Enzymes Present
Flavor
Vegetarian
1

NOW Health Group Inc.

Super Enzymes

NOW Health Group Inc. Super Enzymes 1

Supercharge Your Digestion Game

180 Capsules

Capsule

8

betaine HCl, ox bile extract, papaya fruit powder, pancreatin, bromelain, acid-stable protease, papain, and cellulase.

Unflavored

2

Zenwise, LLC

Digestive Enzymes

Zenwise, LLC Digestive Enzymes 1

Prebiotic, Probiotics, Sea Vegetable Extracts, and Fruit Powders

180 Capsules

Capsule

10

inulin, glucoamylase, amylase, bromelain, cellulase, invertase, lactase, bacterial protease, papain, and lipase

Unflavored

3

JB7, LLC

Physician's ChoiceDigestive Enzymes

JB7, LLC Digestive Enzymes 1

16 Enzymes for Optimal Digestion

60 Capsules

Capsule

16

bromelain, protease 4.5, protease 6.0, papain, peptidase, protease 3.0, amylase, glucoamylase, cellulase, invertase, beta-glucanase, lactase, alpha-galactosidase, xylanase, hemicellulase, and lipase.

unknown

4

KK Nutrition, Inc.

LemmeDebloat

KK Nutrition, Inc. Debloat 1

Triple Action Gut Relief

60 Capsules

Capsule

5

amylase, lactase, lipase, cellulase, and protease.

Unflavored

5

Prestige Brands, Inc.

BeanoGas Prevention and Digestive Enzyme Supplement

Prestige Brands, Inc. Gas Prevention and Digestive Enzyme Supplement 1

Enjoy Meals with Less Gas

100 Capsules

Capsule

1

alpha-galactosidase

6

OLLY

Beat The Bloat Capsules

OLLY Beat The Bloat Capsules 1

Beat The Bloat with OLLY

25 Capsules

Capsule

6

amylase, cellulase, hemicellulase, lactase, alpha-galactosidase, and lipase

7

American Dietaids Co Inc

American HealthOriginal Papaya Digestive Enzyme Chewable Tablets

American Dietaids Co Inc Original Papaya Digestive Enzyme Chewable Tablets 1

Chewable Enzyme Support

600 Capsules

Chewable Tablet

3

papain (from papaya), amylase, and protease (from papaya)

"Original"

8

Threshold Enterprises Ltd.

Source NaturalsEssential Enzymes

Threshold Enterprises Ltd. Essential Enzymes 1

Complete Digestive Support

120 Capsules

Capsules

7

hemicellulase, cellulase, amyloglucosidase, alpha-amylase, lipase, acid-stable protease, and fungal pancreatin

Unflavored

unknown

9

Ogilive Brands, Inc.

Love WellnessBye Bye BloatBBB-LW

Ogilive Brands, Inc. Bye Bye Bloat 1

Say Goodbye to Bloating

60 Capsules

Capsule

6

amylase complex, protease complex, pepsin complex, lipase complex, bromelain complex, and papain complex

Ginger

10

Hum Nutrition Inc

Flatter Me

Hum Nutrition Inc Flatter Me 1

Comprehensive Daily Bloating Relief

60 Capsules

Capsules

18

protease 3.0, protease 4.5, protease 6.0, peptidase, bromelain, neutral bacterial protease, papain, lipase, amylase, glucoamylase, alpha-galactosidase, invertase, diastase, hemicellulase, cellulase, beta-glucanase, phytase, and lactase

Ginger

unknown

If you don't see the product you're looking for, you can request that it be listed.
No.1

NOW Health Group Inc.
Super Enzymes

Super Enzymes 1
Source:amazon.com
Super Enzymes 2
Source:amazon.com
Lowest price
$24.99
Lowest price
$24.99
Unit Count180 Capsules
Unit FormCapsule
Number of Enzymes
8
Enzymes Present
betaine HCl, ox bile extract, papaya fruit powder, pancreatin, bromelain, acid-stable protease, papain, and cellulase.

Supercharge Your Digestion Game

NOW Supplements Super Enzymes is a dietary supplement designed to support healthy digestion with a powerful blend of enzymes, including bromelain, ox bile, pancreatin, and papain. Each capsule is formulated to help break down fats, carbohydrates, and proteins, ensuring optimal nutrient availability from your meals. 


It’s important to note that the product is sensitive to heat and sunlight, which may cause it to melt or get damaged. Additionally, those with specific health conditions or allergies, especially to papaya or pineapple, should consult a physician before use. 

FlavorUnflavored
Vegetarian
Was this Ranking helpful?
No.2

Zenwise, LLC
Digestive Enzymes

Digestive Enzymes 1
Source:amazon.com
Digestive Enzymes 2
Source:amazon.com
Lowest price
$39.97
High
Lowest price
$39.97
High
Unit Count180 Capsules
Unit FormCapsule
Number of Enzymes
10
Enzymes Present
inulin, glucoamylase, amylase, bromelain, cellulase, invertase, lactase, bacterial protease, papain, and lipase

Prebiotic, Probiotics, Sea Vegetable Extracts, and Fruit Powders

These all-natural, vegan Digestive Enzymes feature an array of pre-and probiotics, including Lactobacillus Acidophilus, three kinds of seaweed extract, and powdered fruits and herbs. Zenwise claims that this will help digest what they refer to as the “hard 5”: meat, dairy, fried food, raw vegetables, and alcohol. Customer reviews showcase the positive results that people have experienced from this supplement. Customers have called it “transformative,” and one even said that “these pills have changed [his] life” in regards to mitigating the digestive issues caused by certain foods. 

FlavorUnflavored
Vegetarian
No.3

JB7, LLC
Physician's ChoiceDigestive Enzymes

Lowest price
$19.97
Unit Count60 Capsules
Unit FormCapsule
Number of Enzymes
16
Enzymes Present
bromelain, protease 4.5, protease 6.0, papain, peptidase, protease 3.0, amylase, glucoamylase, cellulase, invertase, beta-glucanase, lactase, alpha-galactosidase, xylanase, hemicellulase, and lipase.

16 Enzymes for Optimal Digestion

Physician's CHOICE Digestive Enzymes offer a comprehensive solution for digestive health by combining 16 beneficial enzymes with organic prebiotics and probiotics. This dual-action approach targets meal-time discomfort, aiding in the breakdown of proteins, carbohydrates, fruits, vegetables, beans, dairy, and fats.


Designed to enhance digestive function, these enzymes work synergistically to provide relief from bloating and discomfort. Each bottle contains 60 capsules, offering a convenient option for those looking to improve their digestive wellness with a scientifically formulated product.

Flavor
Vegetarianunknown
No.4

KK Nutrition, Inc.
LemmeDebloat

Lowest price
$29.99
High Mid
Unit Count60 Capsules
Unit FormCapsule
Number of Enzymes
5
Enzymes Present
amylase, lactase, lipase, cellulase, and protease.

Triple Action Gut Relief

Lemme Debloat 3-in-1 Prebiotic, Probiotic & Digestive Enzyme Capsules provide a comprehensive solution for gut health, targeting occasional bloating, gas, and discomfort. This vegan-friendly supplement combines prebiotics, probiotics, and digestive enzymes to support a balanced gut microbiome and improve digestion.


The five digestive enzymes in the formula—protease, amylase, cellulase, lactase, and lipase—help break down carbohydrates, fats, proteins, and dairy for better nutrient absorption and digestive comfort. The capsules are free from gluten, GMOs, artificial flavors, and synthetic colors, making them suitable for a variety of dietary preferences.

FlavorUnflavored
Vegetarian
No.5

Prestige Brands, Inc.
BeanoGas Prevention and Digestive Enzyme Supplement

Lowest price
$11.98
Unit Count100 Capsules
Unit FormCapsule
Number of Enzymes
1
Enzymes Present
alpha-galactosidase

Enjoy Meals with Less Gas

Beano Ultra 800 is a digestive enzyme supplement designed to prevent gas, bloating, and discomfort caused by hard-to-digest foods like beans, vegetables, and whole grains. Each tablet contains a natural enzyme that helps break down complex carbohydrates, making these foods easier to digest and reducing the likelihood of stomach discomfort.


To use, simply take two Beano tablets before a meal that may cause gas or bloating. It may be effective if taken up to 30 minutes after a meal. The product is also vegetarian-friendly, making it accessible to a wide range of dietary preferences.

Flavor
Vegetarian
No.6

OLLY
Beat The Bloat Capsules

Lowest price
$15.96
Unit Count25 Capsules
Unit FormCapsule
Number of Enzymes
6
Enzymes Present
amylase, cellulase, hemicellulase, lactase, alpha-galactosidase, and lipase

Beat The Bloat with OLLY

OLLY Beat The Bloat Capsules are designed to provide digestive support specifically for women, helping to alleviate occasional digestive issues such as bloating and gas. This supplement combines a blend of digestive enzymes and botanical extracts, including dandelion, fennel, and ginger, to promote comfort and ease stomach discomfort. Each bottle contains 25 capsules, packaged conveniently for daily use.


The digestive enzyme blend in these capsules includes amylase, cellulase, hemicellulase, lactase, alpha-galactosidase, and lipase. These enzymes work together to break down various components of your diet, making digestion smoother.

Flavor
Vegetarian
No.7

American Dietaids Co Inc
American HealthOriginal Papaya Digestive Enzyme Chewable Tablets

Lowest price
$13.23
Unit Count600 Capsules
Unit FormChewable Tablet
Number of Enzymes
3
Enzymes Present
papain (from papaya), amylase, and protease (from papaya)

Chewable Enzyme Support

American Health Original Papaya Digestive Enzyme Chewable Tablets are designed to promote nutrient absorption and aid digestion. These chewable tablets are a convenient after-meal supplement that combines papaya enzymes with chlorophyll and peppermint to help freshen breath. Each serving size is three tablets, making it easy to incorporate into your daily routine.


This supplement is non-GMO, vegan, gluten-free, dairy-free, soy-free, and yeast-free, catering to various dietary preferences and restrictions. It contains three primary digestive enzymes: papain, amylase, and protease, all sourced from papaya, making it vegetarian-friendly. The addition of calcium further supports your overall health.

Flavor"Original"
Vegetarian
No.8

Threshold Enterprises Ltd.
Source NaturalsEssential Enzymes

Lowest price
$12.95
Unit Count120 Capsules
Unit FormCapsules
Number of Enzymes
7
Enzymes Present
hemicellulase, cellulase, amyloglucosidase, alpha-amylase, lipase, acid-stable protease, and fungal pancreatin

Complete Digestive Support

Source Naturals Essential Enzymes is a digestive supplement formulated to aid in the breakdown and absorption of nutrients from food. Each capsule contains a blend of seven enzymes designed to address various aspects of digestion, helping to alleviate issues such as gas and constipation. 


The enzyme blend in Source Naturals Essential Enzymes includes hemicellulase, cellulase, amyloglucosidase, alpha-amylase, lipase, acid-stable protease, and fungal pancreatin. This product is free from common allergens, including yeast, dairy, egg, gluten, corn, soy, and wheat, and contains no sugar, starch, preservatives, or artificial additives.

FlavorUnflavored
Vegetarianunknown
No.9

Ogilive Brands, Inc.
Love WellnessBye Bye BloatBBB-LW

Lowest price
$22.48
Unit Count60 Capsules
Unit FormCapsule
Number of Enzymes
6
Enzymes Present
amylase complex, protease complex, pepsin complex, lipase complex, bromelain complex, and papain complex

Say Goodbye to Bloating

Love Wellness Bye Bye Bloat is a digestive enzyme supplement designed to provide relief from bloating and gas, specifically formulated for women. This supplement combines digestive enzymes with a blend of organic herbs like fenugreek, dandelion, and fennel to support healthy digestion and reduce water retention. 


Each serving size is two capsules, and with 60 capsules per bottle, it provides 30 servings. The product is non-GMO, gluten-free, dairy-free, and free from artificial fragrances, flavors, and dyes, making it a clean choice for digestive health support.

FlavorGinger
Vegetarian
No.10

Hum Nutrition Inc
Flatter Me

Lowest price
$25.99
High Mid
Unit Count60 Capsules
Unit FormCapsules
Number of Enzymes
18
Enzymes Present
protease 3.0, protease 4.5, protease 6.0, peptidase, bromelain, neutral bacterial protease, papain, lipase, amylase, glucoamylase, alpha-galactosidase, invertase, diastase, hemicellulase, cellulase, beta-glucanase, phytase, and lactase

Comprehensive Daily Bloating Relief

HUM Flatter Me is a daily supplement designed to relieve bloating and support overall digestive health. This unique formula features 18 full-spectrum digestive enzymes that help break down proteins, fats, carbohydrates, fibers, and milk sugar, promoting efficient nutrient absorption. 


Additionally, the inclusion of ginger, fennel seed, and peppermint leaf helps soothe the digestive system and further aid in digestion. With a 30-day supply, taking one capsule twice daily before your two main meals can help you manage bloating and digestive discomfort effectively.

FlavorGinger
Vegetarianunknown

What do Enzymes do for Digestion?

Expert
Expert
Digestive enzymes break down larger molecules into smaller particles more readily absorbed by the body.

Enzymes play a crucial role in digestion by breaking down the food we eat into smaller, absorbable nutrients. These proteins act as catalysts, speeding up chemical reactions in the body. Specific enzymes target different types of food: amylases break down carbohydrates, proteases handle proteins, and lipases deal with fats.


This breakdown process allows nutrients to be absorbed into the bloodstream, fueling our bodies and supporting overall health. Without these enzymes, our digestive system would struggle to process food efficiently, leading to discomfort and nutritional deficiencies. Digestive enzyme supplements can aid those who need extra support in this vital process.

When Should I Take a Digestive Enzyme Supplement?

Expert
Expert
15-20 minutes before a meal will facilitate the best absorption and action!

Taking a digestive enzyme supplement can be most effective just before or at the start of a meal. This timing helps ensure that the enzymes are present as food enters your stomach, maximizing their ability to aid digestion. If you frequently experience bloating, gas, or discomfort after eating, supplements might help alleviate these symptoms. Additionally, those with specific conditions like lactose intolerance or pancreatic insufficiency may benefit from enzyme support. Always consult with a healthcare professional to determine the best schedule for your individual needs.

Top 5 Digestive Enzyme Supplement

No. 1: NOW Health Group Inc.Super Enzymes

No. 2: Zenwise, LLCDigestive Enzymes

No. 3: JB7, LLCPhysician's ChoiceDigestive Enzymes

No. 4: KK Nutrition, Inc.LemmeDebloat

No. 5: Prestige Brands, Inc.BeanoGas Prevention and Digestive Enzyme Supplement

View Full Ranking
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