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Probiotics for MenHelping You Find the Best
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Probiotics for MenHelping You Find the Best
  • 10 Best Probiotics for Men of 2025 1
  • 10 Best Probiotics for Men of 2025 2
  • 10 Best Probiotics for Men of 2025 3
  • 10 Best Probiotics for Men of 2025 4
  • 10 Best Probiotics for Men of 2025 5

10 Best Probiotics for Men of 2025

More than ever, men are taking a proactive role in their gut health. Probiotics, a popular supplement with many benefits, help maintain gut health and ensure proper digestion and nutrient absorption.

To help sort through the intricacies of the world of these supplements, we’ve consulted registered dietitian Megan Huff. The points outlined in our buying guide will help you find a probiotic to address your needs. For added convenience, we’ve included our top 10 picks from the best-selling probiotics available on sites like Amazon, ranked according to the criteria in our buying guide. 
Last updated 01/28/2025

Quick List - Top Probiotics for Men

1

Physician's Choice

Physician's Choice60 Billion Probiotic
60 Billion Probiotic

A High Strength Assortment of Probiotics and Prebiotics

2

Culturelle

CulturellePro Strength Digestive Daily Probiotics
Pro Strength Digestive Daily Probiotics

An Extra-Strength Single Strain

3

NewRhythm

Probiotics 50 Billion CFU 20 Strains
Probiotics 50 Billion CFU 20 Strains

50 Billion CFUs of 20 Strains

4

Nature's Bounty

Acidophilus Probiotic
Acidophilus Probiotic

100 Million CFUs of Pure Lactobacillus Acidophilus

5

Wholesome Wellness

Raw Probiotics 100 Billion CFU
Raw Probiotics 100 Billion CFU

3 Trillion CFUs per Bottle

Megan Huff
Expert
Registered Dietitian
Megan Huff

Megan is a registered dietitian and gluten-free food influencer (@sayimafoodie) and owns a virtual nutrition private practice–Nutrition by Megan. Currently, she works as a performance nutrition intern at the United States Naval Academy. She has been quoted for her nutrition expertise in numerous media outlets, including Health, Forbes, People, Clean Plates, EatingWell, and Eat This, Not That! Megan earned her undergraduate degree in nutritional sciences and toxicology-dietetics at the University of California, Berkeley.

Megan Huff's Profile
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Christopher Heffner
Guide
Content Planner at mybest
Christopher Heffner

With over a decade of weightlifting experience, Christopher Heffner is an avid fitness enthusiast who enjoys starting his day with a good workout. He also has a background in engineering and business, bringing a unique blend of technical knowledge and practicality to his endeavors.

Christopher Heffner's Profile
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The expert oversees the Buying Guide only, and does not determine the products and services featured.

Table of Contents

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How to Choose Probiotics for Men

When choosing a probiotic, it's essential to ensure it’s effective and convenient to integrate into your lifestyle. Here, we’ll discuss some critical points to consider.
1

Look for a Blend of Key Strains for Well-Rounded Benefits

Expert
Expert
Different probiotic strains target specific health benefits and can work synergistically to enhance overall gut health.
Look for a Blend of Key Strains for Well-Rounded Benefits

To maximize the benefits of probiotics, it's often beneficial to choose a supplement containing a blend of different strains rather than opting for a single-strain product. Each strain has unique properties and targets specific areas of gut health. Huff provides the following example: "Lactobacillus primarily colonizes the small intestine, supporting digestion and immune function, while Bifidobacterium mainly resides in the large intestine, promoting bowel regularity and reducing inflammation.


Strains of Lactobacillus and Bifidobacterium have garnered attention for their potential to support athletic performance. These beneficial bacteria also help modulate the immune system and may aid in preventing illness, indirectly benefiting physical well-being.

Megan Huff
Registered Dietitian
Megan Huff
[Lactobacillus and Bifidobacterium] may indirectly benefit sports performance but are more supportive rather than directly performance-enhancing.
2

Consider Prebiotics to Improve Nutrient Absorption and Digestion

Expert
Expert
Prebiotics are the food for probiotics, enhancing their activity and supporting the growth of beneficial gut bacteria.
Consider Prebiotics to Improve Nutrient Absorption and Digestion
Prebiotics are a type of dietary fiber that feeds and supports probiotics. By nourishing these beneficial bacteria, prebiotics promote a healthier gut microbiome. Our expert adds that prebiotics "also improve nutrient absorption by stimulating the production of short-chain fatty acids (SCFAs), which help strengthen the gut lining and support intestinal health."
3

Check for 1 to 10 Billion CFUs for an Adequate Dose

Expert
Expert
1-10 billion CFUs is the standard dosage of probiotics, as stated by the National Institutes of Health (NIH).
Check for 1 to 10 Billion CFUs for an Adequate Dose

The NIH recognizes a dosage between 1 and 10 billion Colony-Forming Units (CFUs), used to quantify live probiotic bacteria per dose, as the standard for supplements. Select a supplement containing CFUs in this range to ensure a sufficient dosage.

4

Choose Pills for Convenience, Gummies for Taste

Expert
Expert
Probiotics in pill form are easier to incorporate into a daily routine because they are portable and require no preparation.
Choose Pills for Convenience, Gummies for Taste

Pills and capsules are ideal for those seeking a hassle-free way to add probiotics to their regimen. Huff also points out the portability of pills for those with busy schedules. Additionally, probiotics in pill form tend to provide the best value.


Gummies are a comparatively new format compared to pills. However, they are popular due to their palatable taste and texture, especially for those who don't like swallowing pills. Our registered dietitian also points out that less research has been conducted on gummies than on pills and capsules.

Megan Huff
Registered Dietitian
Megan Huff
Encapsulated probiotics have been studied more extensively than gummies, which typically contain fewer colony-forming units (CFUs).
5

Enteric-Coated Probiotics are Most Effective

Expert
Expert

Enteric coatings help ensure that probiotics reach the intestine without being inactivated by stomach acid.

Enteric-Coated Probiotics are Most Effective
Enteric coatings help protect probiotics from stomach acid, ensuring they reach the intestines intact for maximum effectiveness. While this is beneficial for many strains, Huff adds that some probiotics, like Saccharomyces boulardii, are naturally resistant to stomach acid and may not require this extra protection.
6

Ensure Quality by Looking for Supplements that are Third Party Tested

Expert
Expert

Third-party testing certifications are essential to ensure supplement quality and efficacy.

Ensure Quality by Looking for Supplements that are Third Party Tested

When selecting a probiotic supplement, it is crucial to choose a reputable brand that adheres to high-quality standards. Choose products that have undergone third-party testing. Huff recommends that users look for labels from organizations that include Informed Choice, USP, and NSF Certified for Sport. These certifications ensure that the product meets specific quality and purity standards. 

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10 Best Probiotics for Men Ranking

Here are the best Probiotics for Men, ranked according to some websites and the reviews (as of ). The products are ranked independently by mybest.
Popularity
Filter
Products
Image
Click to purchase
Key features
Details
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving
Servings
Form
Acid-Resistant Coating
Third Party Certifications
1

Physician's Choice

Physician's Choice60 Billion Probiotic

Physician's Choice 60 Billion Probiotic 1

A High Strength Assortment of Probiotics and Prebiotics

60 Billion CFUs

30 Servings

Pill/Capsule

None

2

Culturelle

CulturellePro Strength Digestive Daily Probiotics

Culturelle Pro Strength Digestive Daily Probiotics 1

An Extra-Strength Single Strain

12 Billion CFUs

60 Servings

Pill/Capsule

CDHF Certified

3

NewRhythm

Probiotics 50 Billion CFU 20 Strains

NewRhythm Probiotics 50 Billion CFU 20 Strains 1

50 Billion CFUs of 20 Strains

50 Billion CFUs

30 Servings

Pill/Capsule

None

4

Nature's Bounty

Acidophilus Probiotic

Nature's Bounty Acidophilus Probiotic 1

100 Million CFUs of Pure Lactobacillus Acidophilus

100 Million CFUs

100 Servings

Pill/Capsule

GMP, CDHF, and USDA organic

5

Wholesome Wellness

Raw Probiotics 100 Billion CFU

Wholesome Wellness Raw Probiotics 100 Billion CFU 1

3 Trillion CFUs per Bottle

100 Billion CFUs

30 Servings

Pill/Capsule

FDA, NSF, and GMP certified

6

Garden of Life

Once Daily Men's Probiotics

Garden of Life Once Daily Men's Probiotics 1

15 Probiotic Strains Formulated for Men

50 Billion CFUs

30 Servings

Pill/Capsule

Informed Choice, NSF

7

BioCodex

FlorastorDaily Probiotic Supplement

BioCodex Daily Probiotic Supplement 1

Strengthening Digestive and Immune Health Naturally

50 Servings

Pill/Capsule

GMP, ANSM

8

NOW Foods

Probiotic-10 25 Billion

NOW Foods Probiotic-10 25 Billion 1

Dairy, Soy, and Gluten-Free

25 Billion CFUs

100 Servings

Pill/Capsule

Intertek GMP, Informed-Sport

9

Earth's Pearl

Probiotic + Prebiotic

Earth's Pearl Probiotic + Prebiotic 1

4 Billion Easy to Swallow CFUs

4 Billion CFUs

60 Servings

Pill/Capsule

GMP, NSF

10

Align

Align24/7 Digestive Support*§ Probiotic Supplement

Align 24/7 Digestive Support*§ Probiotic Supplement 1

A Supplement Containing Only Bifidobacterium Infantus

1 Billion CFUs

63 Servings

Pill/Capsule

None

If you don't see the product you're looking for, you can request that it be listed.
No.1

Physician's Choice
Physician's Choice60 Billion Probiotic

60 Billion Probiotic 1
Source:amazon.com
60 Billion Probiotic 2
Source:amazon.com
Lowest price
$23.97
Mid
Lowest price
$23.97
Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving60 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
None

A High Strength Assortment of Probiotics and Prebiotics

This is a high-potency probiotic containing 10 different strains (including Bifidobacterium and Lactobacillus) and prebiotics in a time-release capsule. As the name implies, it includes six times our recommended per-serving dose of CFUs. Many customers have reported improved digestion, reduced bloating, and a stronger immune system (becoming sick less often and with less severity).

Servings30 Servings
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No.2

Culturelle
CulturellePro Strength Digestive Daily Probiotics

Lowest price
$31.49
Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving12 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
CDHF Certified

An Extra-Strength Single Strain

This supplement features a single probiotic strain (12 billion CFUs of Lactobacillus rhamnosus) specifically chosen for its digestive health benefits. Culturelle claims they referenced “over 1000 scientific studies” when selecting their probiotic strain. Customers have reported relief from common digestive issues like bloating, gas, and constipation. Some users have mentioned that the blister packaging makes it more convenient to bring these pills when traveling.

Servings60 Servings
No.3

NewRhythm
Probiotics 50 Billion CFU 20 Strains

Lowest price
$16.99
Low
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving50 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
None

50 Billion CFUs of 20 Strains

This supplement from NewRhythm combines 50 billion CFUs of probiotics and prebiotics to support gut health and overall well-being. The probiotic strains used are focused on different varieties of Bifidobacterium and Lactobacillus. Customers appreciate the convenient, stomach-acid-resistant capsule form and the noticeable improvement in digestion and energy levels that they provide.

Servings30 Servings
No.4

Nature's Bounty
Acidophilus Probiotic

Lowest price
$18.94
Low Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving100 Million CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
GMP, CDHF, and USDA organic

100 Million CFUs of Pure Lactobacillus Acidophilus

This probiotic from Nature’s Bounty contains only Lactobacillus acidophilus, a strain well-known for its digestive health benefits. While it only includes 100 million CFUs of probiotics, this supplement is free of common allergens. Customers have reported improved digestion and reduced bloating. Some users have mentioned that this product offers good value for the money, especially those not seeking an exceptionally powerful probiotic.
Servings100 Servings
No.5

Wholesome Wellness
Raw Probiotics 100 Billion CFU

Lowest price
$27.99
Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving100 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
FDA, NSF, and GMP certified

3 Trillion CFUs per Bottle

Wholesome Wellness offers a raw, unpasteurized formula with a high CFU count of 100 billion CFUs spread across 34 strains of probiotics per serving. It also includes prebiotics. Users praise this supplement's potency, effectiveness, and quick effects, which is no surprise given that it offers the most CFUs of any entry on our list. Some customers mentioned having problems getting their desired results from less powerful probiotics but had better luck with this one.
Servings30 Servings
No.6

Garden of Life
Once Daily Men's Probiotics

Lowest price
$32.19
Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving50 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
Informed Choice, NSF

15 Probiotic Strains Formulated for Men

This supplement from Garden of Life is specifically formulated for men's health, supporting digestive and immune function. It features 35 billion CFUs of Lactobacillus and 15 billion CFUs of Bifidobacterium per capsule. It also contains a blend of prebiotic fibers. Customers appreciate the convenient once-daily dosage and the noticeable improvement in digestion and overall well-being.

Servings30 Servings
No.7

BioCodex
FlorastorDaily Probiotic Supplement

Lowest price
$62.06
High
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
GMP, ANSM

Strengthening Digestive and Immune Health Naturally

Florastor's Daily Probiotic Supplement offers dual-action support for digestive and immune health. This probiotic supplement contains 250mg of the exclusive probiotic strain Saccharomyces boulardii, which has been extensively researched for over 65 years. 


It helps strengthen digestive support by flushing out bad bacteria and promoting the growth of good bacteria. By breaking down carbs and sugars, Florastor improves digestion and supports immune health. These easy-to-take capsules are suitable for both men and women and can be taken at the same time as antibiotics, making them a convenient choice for maintaining gut health.

Servings50 Servings
No.8

NOW Foods
Probiotic-10 25 Billion

Lowest price
$20.99
Low Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving25 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
Intertek GMP, Informed-Sport

Dairy, Soy, and Gluten-Free

This supplement provides 10 strains of probiotics for comprehensive gut health support and 25 billion CFUs in each capsule for more than sufficient dosage. Customers appreciate the affordable price and the noticeable improvement in digestion. Some users find the capsule size a bit large. However, with 100 doses per bottle, customers mention this probiotic's value aspect.
Servings100 Servings
No.9

Earth's Pearl
Probiotic + Prebiotic

Lowest price
$29.87
Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving4 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
GMP, NSF

4 Billion Easy to Swallow CFUs

This supplement combines probiotics and prebiotics for optimal gut health. This package provides two months' worth of doses for ongoing digestive aid. Users praise the effectiveness in improving digestion, reducing bloating, and boosting energy levels. They also mention how the compact pearl-like capsule is easy to swallow.
Servings60 Servings
No.10

Align
Align24/7 Digestive Support*§ Probiotic Supplement

Lowest price
$46.99
High Mid
Lactobacillus
Bifidobacterium
Probiotic Blend
Prebiotics
CFUs per Serving1 Billion CFUs
Form
Pill/Capsule
Acid-Resistant Coating
Third Party Certifications
None

A Supplement Containing Only Bifidobacterium Infantus

This proprietary single-strain probiotic from Align focuses on digestive health. Customers often report relief from digestive issues like bloating, gas, and constipation. However, some users find the price point a bit high for a supplement containing a two-month supply of pills containing only 1 billion CFUs per serving.

Servings63 Servings

Top 5 Probiotics for Men

No. 1: Physician's ChoicePhysician's Choice60 Billion Probiotic

No. 2: CulturelleCulturellePro Strength Digestive Daily Probiotics

No. 3: NewRhythmProbiotics 50 Billion CFU 20 Strains

No. 4: Nature's BountyAcidophilus Probiotic

No. 5: Wholesome WellnessRaw Probiotics 100 Billion CFU

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The descriptions of each product are referenced from content available on manufacturer, brand, and e-commerce sites.

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