10 Best Vitamin D3 and K2 Supplements [Registered Dietitian-Reviewed]
For this comprehensive guide, we teamed up with registered dietitian nutritionist Kathy Shattler. Our team also put together a ranking of the best vitamin D3 and K2 supplements in the U.S. to get you started on your search. From flexible liquid options to softgels with added absorption enhancers like coconut oil, we’ll highlight the top products on the market to fit your specific needs. Whether you aim to maintain bone density, support heart health, or avoid the side effects of over-supplementation, this guide will steer you toward the right solution.
Quick List - Top Vitamin D3 and K2 Supplement
Micro Ingredients
High-Potency D3 and MK-7 K2 with MCT Oil for Maximum Absorption
A Registered Dietitian Nutritionist for over 25 years, Kathy has mastered numerous medical specialties and teaching methods: health promotion, counseling, academic teaching, endocrinology, psychiatry/mental health, supplements, diabetes, obesity, heart disease, aging, and alternative medicine. Experiences include: -Managing her own telehealth/nutrition consulting business -Directing a continuing education program for RDs and nurses -Consulting for long-term care regulatory affairs -Working with State and local health departments -Coordinating diabetes education programs Her experiences led her to reach people with life-changing information as a medical editor and writer. For over five years, Kathy has acquired increasingly complex roles. Passionate about the root causes of disease, she obtained her certification in Integrative Medicine and Functional Nutrition from the Academy of Nutrition and Dietetics three years ago. This series continues to influence her approach to writing.
mybest US' editing team consists of experienced members who have backgrounds in writing, editing, translation, and more. We are dedicated to researching what makes a product or service the best to users in the US in order to create top-quality articles. From skincare, to kitchen appliances, and to DIY supplies, our mission is to find the best ones for you.
The expert oversees the Buying Guide only, and does not determine the products and services featured.
Table of Contents
- Should You Take Vitamin D3 and K2 Together?
- How to Choose Vitamin D3 and K2 Supplements - Buying Guide
- Check the Dosage: A Balanced Supplement Should Offer a D3 to K2 Ratio of Around 1,000:101
- Select the Form of K2 with the Benefits You Seek2
- Look for Products with MCT (Medium-Chain Triglyceride) Oil to Enhance Absorption3
- Consider Formulations with Magnesium to Support Cardiovascular, Heart, and Bone Health4
- Choose the Form of Supplement That Suits Your Condition5
- Check for Products That Have Been Third-Party Tested for Purity, Potency, and Safety6
- 10 Best Vitamin D3 and K2 Supplements Ranking
- No. 1Sports Research | Vitamin D3 + K2 with Coconut MCT Oil
- No. 2Dr. Berg | D3 & K2 Vitamin (10,000 IU)
- No. 3Micro Ingredients | Micro Ingredients｜Vitamin D3 K2 Supplement Softgels
- No. 4Bronson | Bronson｜Vitamin K2 MK-7 Plus Vitamin D3
- No. 5Nature Made | Nature Made｜Vitamin D3 + K2 Softgels
- 5 more products
- Potential Side Effects of Vitamin D3 and K2
- Other Popular Supplements to Check Out
Should You Take Vitamin D3 and K2 Together?
Supplementing with vitamins D3 and K2 may synergistically support cardiovascular and bone health by improving calcium metabolism and preventing vascular calcification.
Taking vitamin D3 and K2 together is generally recommended, as these two fat-soluble vitamins work synergistically to support bone health and prevent conditions like osteoporosis. Vitamin D3 helps your body absorb calcium from your diet, ensuring sufficient amounts of this essential mineral are available in the bloodstream.
However, without vitamin K2, the calcium absorbed by D3 may not be directed appropriately, potentially leading to calcification in soft tissues, such as the arteries. K2 is critical in ensuring that calcium is deposited in the bones where it is needed rather than in the arteries. This helps promote strong bones while preventing calcium buildup in unwanted areas.
Additionally, the combination of D3 and K2 is beneficial for cardiovascular health. Vitamin K2 inhibits arterial calcification and arterial stiffening by activating matrix GLA protein (MGP), a key inhibitor of calcium deposits on the artery walls. Adequate K2 intake can, therefore, lower the risk of vascular damage, promoting better arterial health.
This combination also has additional benefits for individuals with type 2 diabetes, as studies suggest that D3 and K2 together can improve insulin action in overweight patients, helping manage blood sugar levels and reduce associated health risks.
How to Choose Vitamin D3 and K2 Supplements - Buying Guide
Check the Dosage: A Balanced Supplement Should Offer a D3 to K2 Ratio of Around 1,000:10
The recommended daily dosage of vitamin D3 and K2 supplements can vary based on individual needs.
According to Poland's 2023 vitamin D guidelines, general recommendations from this report now suggest taking 1,000-2,000 IU of vitamin D3 daily.
For vitamin K, the National Institutes of Health (NIH) recommends that men consume 120 mcg of vitamin K daily, while women need 90 mcg.
There is no strict ratio for D3 to K2 intake, as individual vitamin D requirements differ. However, common suggestions are to take 10 mcg of K2 for every 1,000 IU of D3 (or 50 mcg of K2 for every 5,000 IU of D3). This ratio helps support calcium balance and cardiovascular health.
Vascular calcification (VC), common in end-stage kidney disease and linked to K2 depletion, was reduced by 360 mcg of K2 daily in over 61% of dialysis patients, while postmenopausal women showed arterial stiffness improvement with just 180 mcg.
The results of these studies indicate that outcomes are responsive to varying dosages of vitamin K2, which may differ based on the medical condition of the population being treated.
Select the Form of K2 with the Benefits You Seek
Choose MK-7 (Menaquinone-7) for the Most Bioavailable and Effective Form of K2
MK-7 is the most bioavailable and longest-lasting form of K2, meaning it stays in the bloodstream longer, allowing for more effective calcium regulation. This form is particularly beneficial for older adults or postmenopausal women at a higher risk of bone density loss or osteoporosis. MK-7 helps direct calcium to the bones and away from arteries, reducing the likelihood of calcium deposits in arteries that can lead to cardiovascular issues.
MK-7 is also ideal for those seeking long-term health benefits with less frequent dosing. Since it remains active in the body longer than the MK-4 form, individuals can maintain consistent levels of K2 with a once-daily supplement.
Individuals concerned about heart health, especially those with a family history of heart disease or arterial calcification, should opt for MK-7 to ensure their calcium is properly utilized and does not contribute to arterial plaque buildup.
There are two forms of MK-7, cis and trans, and the label should differentiate which form is being used. You should opt for the trans form of this supplement. The cis form is cheaper, but the trans form entirely determines therapeutic effectiveness.
Pick MK-4 (Menaquinone-4) if You're Seeking Short-Term, High Dose Benefits
MK-4 is particularly beneficial for lowering LDL (bad cholesterol), which helps reduce plaque buildup in the arteries and lowers the risk of cardiovascular diseases.
MK-4 can decrease atherogenesis by reducing low-density lipoproteins or LDL (bad cholesterol), which decreases the risk of plaque buildup in the arteries. This helps prevent the development of cardiovascular disease by promoting better lipid regulation and artery health.
MK-4 is particularly suitable for those who already take frequent doses of other supplements or medications and prefer flexibility in adjusting the dosage of K2 throughout the day. Since MK-4 clears the body more quickly, some may prefer to take it multiple times a day for a more controlled, consistent intake.
Additionally, research has shown that MK-4 plays a role in bone health and has been used in higher doses of 45 mg to treat osteoporosis, which may benefit individuals under medical supervision needing specific bone support.
Look for Products with MCT (Medium-Chain Triglyceride) Oil to Enhance Absorption
People with digestive sensitivities or conditions impairing fat absorption, such as celiac disease or gallbladder issues, can also benefit from MCT oil supplements. The liver easily digests and directly absorbs MCTs, making them ideal carriers for vitamins D3 and K2.
Consider Formulations with Magnesium to Support Cardiovascular, Heart, and Bone Health
Magnesium supports bone health and regulates heart rhythm, blood pressure, and overall cardiovascular function. When combined with D3 and K2, magnesium enhances the effectiveness of these vitamins by ensuring proper calcium metabolism.
For Cardiovascular Health: Magnesium helps prevent calcium from building up in the arteries, a risk factor for heart disease. This combination is particularly beneficial for those focused on maintaining heart health and preventing arterial calcification.
For Bone Health: Magnesium is essential for activating vitamin D3 and improving bone calcium absorption. Vitamin D3 may not function effectively without adequate magnesium, and calcium may deposit in soft tissues rather than being directed to the bones. Adding magnesium to the formula is helpful for older adults or those at risk of osteoporosis, as it ensures calcium is utilized correctly and contributes to bone health rather than causing harm to arteries or tissues.
Choose the Form of Supplement That Suits Your Condition
Opt for an Oil-Based Capsule or Softgel for Better Absorption
Oil-based capsules improve the bioavailability of fat-soluble vitamins such as D and K by enhancing their digestion and absorption through the lymphatic or hepatic systems.
Since both D3 and K2 are fat-soluble, they must be taken with fat for optimal absorption. Oil-based softgels provide this essential fat within the capsule itself, ensuring that the vitamins are absorbed efficiently, even if the supplement is taken on an empty stomach or with a low-fat meal. This form is ideal for individuals with poor fat intake or those seeking a more reliable, convenient absorption method.
Softgels are often smaller and smoother compared to tablets, making them easier to take, especially for older adults or those who struggle with swallowing pills.
Softgels provide a pre-measured dose of both vitamins, offering consistency and accuracy in supplementation, which is beneficial for people managing specific health concerns like bone density or cardiovascular health.
Go for a Liquid Form if You Prefer Flexible Dosing or Have Difficulty Swallowing Pills
Liquid supplements allow for easy dosage adjustment to tailor your intake to your specific healthcare needs. This is especially useful for children, older adults, or those needing to increase or decrease their dosage gradually.
Liquids are generally absorbed more rapidly by the body than capsules or tablets, allowing for quicker utilization of the vitamins. This makes liquid vitamin D3 and K2 ideal for individuals who need immediate health support, such as those with severe vitamin deficiencies or people managing acute health conditions related to bone density or cardiovascular health.
Drops or liquid supplements are often free of unnecessary fillers, providing a purer option for health-conscious consumers. Their liquid form also makes them excellent for individuals with swallowing difficulties who prefer to ingest supplements mixed in food, drinks, or smoothies.
Check for Products That Have Been Third-Party Tested for Purity, Potency, and Safety
Consumers should actively look for a Certificate of Analysis (COA) for each product, demonstrating that it has been rigorously tested for quality and purity.
A certification seal from reputable organizations such as NSF, USP, GMP, or ConsumerLab.com indicates that the product has met specific standards for safety and efficacy. These certifications serve as a reliable benchmark for consumers, helping them select high-quality supplements that are both effective and safe for consumption.
10 Best Vitamin D3 and K2 Supplements Ranking
Products | Image | Click to purchase | Key features | Details | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
D3 Dosage | K2 Dosage | K2 Type | MCT Oil | Magnesium | Form | Third-Party Tested | Organic | |||||
1 | Sports Research Vitamin D3 + K2 with Coconut MCT Oil | | Plant-Based Power for Bone and Heart Health | 5000IU | 100mcg | MK-7 | Softgel | |||||
2 | Dr. Berg D3 & K2 Vitamin (10,000 IU) | | Advanced Formula for Superior Absorption | 10000IU | 100mcg | MK-7 | Veg capsule | |||||
3 | Micro Ingredients Micro Ingredients｜Vitamin D3 K2 Supplement Softgels | | High-Potency D3 and MK-7 K2 with MCT Oil for Maximum Absorption | 5000IU | 200mcg | MK-7 | Softgel | |||||
4 | Bronson Bronson｜Vitamin K2 MK-7 Plus Vitamin D3 | | Advanced Bone and Heart Health Support | 5000IU | 90mcg | MK-7 | Veg capsule | |||||
5 | Nature Made Nature Made｜Vitamin D3 + K2 Softgels | | K2 and D3 for Enhanced Calcium Utilization and Artery Health | 5000IU | 100mcg | MK-7 | Softgel | |||||
6 | Pure Encapsulations Vitamin D3 & K2 | | Allergen-Free D3 + K2 for Bone, Vascular, and Immune Support | 4000IU | 100mcg | MK-7 | Veg capsule | |||||
7 | Nusava Organic Vitamin D3 K2 Drops w MCT Oil Omega 3 | | Liquid D3 + K2 with Omega-3 for Fast Absorption | 5000IU | 120mcg | MK-7、MK-4 | Liquid | |||||
8 | NOW Foods Vitamin D-3 & K-2 Capsules | | D3 & K2 in Allergen-Free Capsules | 1000IU | 45mcg | MK-4 | Veg capsule | |||||
9 | Metagenics Vitamin D3 10,000 + K | | High-Potency D3 + MK-7 K2 with a Satisfaction Guarantee | 10000IU | 110mcg | MK-7 | Softgel | |||||
10 | Thorne Vitamin D + K2 Liquid | | Customizable Liquid D3 + K2 Trusted by Health Professionals | 1000IU | 200mcg | MK-4 | Liquid | |||||
Sports ResearchVitamin D3 + K2 with Coconut MCT Oil
| D3 Dosage | 5000IU |
|---|---|
| K2 Dosage | 100mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
Plant-Based Power for Bone and Heart Health
Sports Research Vitamin D3 + K2 combines the potent benefits of 5,000 IU of vegan-certified D3 with 100 mcg of K2 MK-7 to support optimal bone and cardiovascular health. Sourced from lichen, the plant-based D3 in these softgels is ideal for those following a vegan lifestyle, while the K2, derived from chickpea, directs calcium into the bones and teeth, helping to maintain strong bones and reduce arterial plaque formation. This powerful duo is blended with organic coconut oil to enhance absorption, ensuring you get the most out of every dose.
Free from soy and gluten, these easy-to-swallow softgels are designed to fit seamlessly into your daily routine, providing a convenient way to maintain your vitamin D and K levels. With 60 softgels per bottle, Sports Research offers a two-month supply of high-quality, plant-based nutrition, supporting your bone strength and heart health for a well-rounded approach to overall wellness.
| Form | Softgel |
|---|---|
| Third-Party Tested | |
| Organic |
Dr. BergD3 & K2 Vitamin (10,000 IU)
| D3 Dosage | 10000IU |
|---|---|
| K2 Dosage | 100mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
Advanced Formula for Superior Absorption
Dr. Berg’s Vitamin D3 & K2 supplement combines a powerful blend of 10,000 IU of vitamin D3 and 100 mcg of MK7 vitamin K2 to support optimal bone, heart, and immune health. This unique formula includes MCT powder, purified bile salts, zinc, and magnesium, ensuring that your body effectively absorbs and utilizes these essential nutrients. Adding K2 helps guide calcium to the bones and teeth rather than letting it accumulate in the arteries, promoting cardiovascular health.
The addition of magnesium enhances the absorption and metabolism of vitamin D. Without magnesium, vitamin D is stored in the body and cannot be used.
Designed for those who seek maximum absorption, Dr. Berg’s Vitamin D3 K2 supplement is an excellent choice for anyone looking to enhance their vitamin D levels and overall health. Each bottle contains 120 capsules, providing a convenient four-month supply of these vital nutrients. This supplement is perfect for individuals needing a higher dose of vitamin D3 while also benefiting from the added support of vitamin K2, zinc, and magnesium for comprehensive wellness.
While this supplement contains an amount of vitamin D in excess of the tolerable upper limit of 4,000 IU/daily, the addition of vitamin K has a protective effect on D hypervitaminosis, thus preventing the usual side effects associated with excessive D3 consumption.
| Form | Veg capsule |
|---|---|
| Third-Party Tested | |
| Organic |
Micro IngredientsMicro Ingredients ｜ Vitamin D3 K2 Supplement Softgels
| D3 Dosage | 5000IU |
|---|---|
| K2 Dosage | 200mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
High-Potency D3 and MK-7 K2 with MCT Oil for Maximum Absorption
Micro Ingredients delivers a high-potency combination of 10,000 IU of Vitamin D3 and 200 mcg of K2 (MK-7) per softgel, designed for optimal calcium absorption and bone health. Adding MCT oil ensures that these fat-soluble vitamins are efficiently absorbed by the body, maximizing their effectiveness in supporting bone density and cardiovascular health.
This formula is free from genetically modified ingredients or GMOs, gluten, soy, dairy, and preservatives. It is designed for those seeking a high-strength option without unwanted additives. Each batch undergoes third-party testing to ensure purity and potency, making it a trusted choice for individuals with higher vitamin D needs.
| Form | Softgel |
|---|---|
| Third-Party Tested | |
| Organic |
BronsonBronson ｜ Vitamin K2 MK-7 Plus Vitamin D3
| D3 Dosage | 5000IU |
|---|---|
| K2 Dosage | 90mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
Advanced Bone and Heart Health Support
This supplement provides a powerful combination of 5,000 IU of Vitamin D3 and 90 mcg of Vitamin K2 MK-7 in each capsule. This dynamic duo is designed to support strong bones and cardiovascular health by ensuring calcium is effectively absorbed and directed to where it's needed most — your bones and teeth — rather than accumulating in your arteries. The non-GMO formula makes this supplement a trusted choice for those looking to enhance their vitamin D and K intake.
With 120 easy-to-swallow capsules, Bronson Vitamin K2 with D3 offers a convenient way to maintain optimal levels of these essential vitamins. Including MK-7, the most bioactive form of Vitamin K2, ensures long-lasting effectiveness, making it ideal for daily use. This vitamin D and K complex is excellent for individuals seeking comprehensive bone density, heart health, and overall wellness support.
| Form | Veg capsule |
|---|---|
| Third-Party Tested | |
| Organic |
Nature MadeNature Made ｜ Vitamin D3 + K2 Softgels
| D3 Dosage | 5000IU |
|---|---|
| K2 Dosage | 100mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
K2 and D3 for Enhanced Calcium Utilization and Artery Health
Nature Made Vitamin D3 + K2 Softgels offer a simple solution for those with higher Vitamin D requirements. They feature 100 mcg of K2 to support calcium metabolism and 5,000 IU of D3 to aid in absorption. This combination is formulated to support both bone health and arterial function, helping to direct calcium to where it’s needed most — your bones.
This product is free from gluten, synthetic dyes, and artificial flavors and is manufactured in the USA using high-quality global ingredients. It’s an ideal choice for those seeking to improve bone density or maintain healthy arteries with a focus on quality and purity.
| Form | Softgel |
|---|---|
| Third-Party Tested | |
| Organic |
Pure EncapsulationsVitamin D3 & K2
| D3 Dosage | 4000IU |
|---|---|
| K2 Dosage | 100mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
Allergen-Free D3 + K2 for Bone, Vascular, and Immune Support
Pure Encapsulations Vitamin D3 & K2 offers a clean, allergen-free formula designed to support bone health, vascular function, and immune defense. This supplement has a precise dose of 4,000 IU of D3 and 100 mcg of K2. It aims to improve calcium metabolism, ensuring calcium is effectively utilized in the bones and not deposited in soft tissues like arteries.
The product is made from premium ingredients and is free from wheat, eggs, peanuts, gluten, artificial colors, and GMOs, making it suitable for those with dietary restrictions. Pure Encapsulations also claims to test products in cGMP-certified laboratories to ensure quality.
| Form | Veg capsule |
|---|---|
| Third-Party Tested | |
| Organic |
NusavaOrganic Vitamin D3 K2 Drops w MCT Oil Omega 3
| D3 Dosage | 5000IU |
|---|---|
| K2 Dosage | 120mcg |
- K2 Type
- MK-7、MK-4
- MCT Oil
- Magnesium
Liquid D3 + K2 with Omega-3 for Fast Absorption
Nusava offers a convenient liquid D3 + K2 supplement that provides 5,000 IU of Vitamin D3 and 120 mcg of K2 in each serving. The formula also includes omega-3 and MCT oil, both of which help support better absorption of these fat-soluble vitamins.
This USA-made product is suitable for individuals seeking a fast-acting liquid option. It’s particularly beneficial for those who prefer a liquid format for easier dosing or quicker nutrient uptake.
| Form | Liquid |
|---|---|
| Third-Party Tested | |
| Organic |
NOW FoodsVitamin D-3 & K-2 Capsules
| D3 Dosage | 1000IU |
|---|---|
| K2 Dosage | 45mcg |
- K2 Type
- MK-4
- MCT Oil
- Magnesium
D3 & K2 in Allergen-Free Capsules
NOW Foods' Vitamin D-3 & K-2 capsules deliver 1,000 IU of Vitamin D3 and 45 mcg of K2 per serving. They support bone health and cardiovascular function by promoting calcium absorption and directing it away from arteries.
This product is certified non-GMO, kosher, and soy-free and manufactured in a facility that adheres to Good Manufacturing Practices (GMP), ensuring high quality and purity. It’s a reliable option for those seeking daily support for bone and heart health.
| Form | Veg capsule |
|---|---|
| Third-Party Tested | |
| Organic |
MetagenicsVitamin D3 10,000 + K
| D3 Dosage | 10000IU |
|---|---|
| K2 Dosage | 110mcg |
- K2 Type
- MK-7
- MCT Oil
- Magnesium
High-Potency D3 + MK-7 K2 with a Satisfaction Guarantee
Metagenics Vitamin D3 10,000 + K features a potent 10,000 IU of vitamin D3 and 110 mcg of K2 as MK-7. It may be suitable for those needing a higher dose of D3 to support bone health and immune function. The dosage is high, so consult with a doctor to see if this supplement is right for you.
The formula is non-GMO and gluten-free, and the product comes with a 60-day satisfaction guarantee for peace of mind. It's an ideal choice for individuals with high vitamin D needs, particularly those at risk for deficiencies.
| Form | Softgel |
|---|---|
| Third-Party Tested | |
| Organic |
ThorneVitamin D + K2 Liquid
| D3 Dosage | 1000IU |
|---|---|
| K2 Dosage | 200mcg |
- K2 Type
- MK-4
- MCT Oil
- Magnesium
Customizable Liquid D3 + K2 Trusted by Health Professionals
Thorne’s Vitamin D + K2 liquid supplement offers a convenient and flexible way to consume both D3 and K2, supporting bone, muscle, and cardiovascular health. The standard dosage is 1,000 IU of D3 and 200 mcg of K2. The product features a self-dispensing top, ensuring accurate and customizable dosing, making it particularly suitable for those who need precise control over their intake.
Thorne has a reputation for quality and trust among health professionals. They even partner with the Mayo Clinic. Thorne’s liquid D3 + K2 supplement is a reliable choice for anyone seeking to optimize their vitamin intake without capsules or tablets.
| Form | Liquid |
|---|---|
| Third-Party Tested | |
| Organic |
Potential Side Effects of Vitamin D3 and K2
When taken in recommended doses, the combination of vitamin D3 and K2 is generally considered safe. However, taking excessive amounts of D3 can lead to hypercalcemia, where too much calcium accumulates in the blood. This hypervitaminosis can result in symptoms like nausea, vomiting, fatigue, and kidney stones. While K2 helps direct calcium to the bones and away from arteries and has hypervitaminosis protective effects for D3, over-supplementation with D3 can still pose risks, especially if taken in extremely high doses without medical supervision over a prolonged period.
Individuals on blood-thinning medications, like warfarin, need to be cautious with vitamin K2, as it can interfere with the medication's effectiveness by promoting blood clotting. Additional medications that may be affected include anti-seizure drugs, antibiotics, fat-blockers, and others. It's crucial to follow dosage guidelines and consult with a healthcare provider, especially for those with pre-existing conditions or taking any medication.
Top 5 Vitamin D3 and K2 Supplement
No. 1: Sports Research｜Vitamin D3 + K2 with Coconut MCT Oil
No. 2: Dr. Berg｜D3 & K2 Vitamin (10,000 IU)
No. 3: Micro Ingredients｜Micro Ingredients｜Vitamin D3 K2 Supplement Softgels
No. 4: Bronson｜Bronson｜Vitamin K2 MK-7 Plus Vitamin D3
No. 5: Nature Made｜Nature Made｜Vitamin D3 + K2 Softgels
View Full RankingThe descriptions of each product are referenced from content available on manufacturer, brand, and e-commerce sites.
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