10 Best Vitamin B12 Supplements in 2022 (Registered Dietitian-Reviewed)
Are you struggling with low energy levels, or poor mental health and cognitive functions? If so, then you may be suffering from a B12 deficiency. Vitamin B12 may be one of the most disregarded vitamins of all. That could be because people don't know of its role in making many systems inside our body work in the right way. When you lack the vitamin in your body, supplementing becomes a pressing priority.
That's why we've researched the best vitamin B12 supplements available and chose the B12 Time Release Tablets by Salt Lake Supplements as our best. It's easy to use, suitable for vegans, and is quickly absorbed into the body. We've selected another nine options and also have a comprehensive buying guide to help you make your choice.
Quick List - Top Vitamin B12 Supplements
Nature Made
Best for Slow-Release and Maximum Absorption
Rachel Binkley is a registered dietitian who helps individuals develop healthy habits that fit into their lifestyle. She recommends adequate intakes of all micronutrients to help prevent deficiency as well as chronic conditions that may arise. You can keep up with her recipes, lifestyle, and more on Instagram or her blog, S'more Satisfaction.
mybest US' editing team consists of experienced members who have backgrounds in writing, editing, translation, and more. We are dedicated to researching what makes a product or service the best to users in the US in order to create top-quality articles. From skincare, to kitchen appliances, and to DIY supplies, our mission is to find the best ones for you.
The expert oversees the Buying Guide only, and does not determine the products and services featured.
Why You Can Trust Us
Every mybest article is crafted with hours of in-depth research and interviews with experts. Each month, we are continually expanding our database of products based on our research. By emphasizing user insight and reliable information, we deliver trustworthy content to readers.
Do I Need a Vitamin B12 Supplement?
Good candidates for needing vitamin B12 supplements include pregnant women, who need this vitamin in particular to support the development of the brain and central nervous system of the growing fetus. Plant-based foods lack the vitamin, so vegans and vegetarians might need to supplement their body with vitamin B12, as might anyone with a digestive disorder such as heartburn or Crohn’s disease.
Sometimes doctors recommend vitamin B12 supplements to senior adults as they tend to eat less as they age, leading to a decreased level of vitamin B12 and a greater risk of associated concerns. In some cases, patients undergoing depression treatment are also prescribed to have vitamin B12 supplements.
Pernicious anemia is a vitamin B12 deficiency anemia that occurs in those with autoimmune diseases attacking the immune system. It can also occur in people who have undergone surgery to remove a part of the stomach. People with these concerns might experience difficulty with vitamin B12 absorption.
Most food is absorbed in the small intestine. When there are diseases or complications that interfere with intestinal function, it can make it much harder to meet your micronutrient needs. In some cases, doctors even recommend supplementation through routes other than the gastrointestinal tract. Certain medications have also been shown to affect vitamin B12 absorption.
How We Chose Our Products
We picked our 10 best vitamin B12 supplements based on the following criteria:
- What the potency of the vitamin is
- Whether it contains methylcobalamin or cyanocobalamin
- If it has any official certifications
- Whether it is suitable for vegans
- Which form the vitamin takes
Make sure you keep these factors in mind when you look through our 10 best and check our Buying Guide below for more information.
How to Choose a Vitamin B12 Supplement - Buying Guide
Sometimes when your body doesn't react as expected and doesn't absorb vitamins or minerals properly, it becomes essential for doctors to help you fill the nutritional gap.
Vitamin B12 is reputed for its importance in getting a lot of things to function properly inside our body. This guide is an insight into making your vitamin B12 supplement purchase easier.
Know Your Recommended Daily Intake in Micrograms (mcg)
As a general guideline, anyone above the age of 14 needs 2.4 mcg of vitamin B12 daily. Children between 9 to 13 years of age need only 1.8 mcg, whereas those in the age group of 4 to 8 years need only 1.2 mcg of vitamin B12.
Babies and toddlers can have up to 0.9 mcg of vitamin B12. Pregnant women and lactating mothers need 2.6 mcg and 2.8 mcg, respectively. But ultimately, the amount of vitamin B12 you need should be determined by your physician.
Choose Between the Two Main Types of Vitamin B12
Methylcobalamin and cyanocobalamin are the two common vitamin B12 types that you find in supplements. Hydroxycobalamin and adenosylcobalamin are also found in some supplements but aren't as common.
Methylcobalamin Remains in the Body Longer
Methylcobalamin can be found in supplements labeled as methyl, instead of methylcobalamin. This form is the most preferred for being the natural form of B12 as it is commonly found in many different foods, such as eggs and fish. Methylcobalamin increases your levels of B12 and replaces red blood cells.
It is known to stay in the body longer than other forms, so that eliminates the need to take it often. However, to get the most out of methylcobalamin, you may have to take it alongside adenosylcobalamin, which is another form of B12. Adenosylcobalamin helps metabolize fats and amino acids and is also essential to creating the protective sheaths that cover nerve cells.
Cyanocobalamin is the Most Stable Form of B12 in Supplements
Cyanocobalamin is the lab synthesized version of vitamin B12, which can be commonly found in fortified cereals and other such foods. It is a very stable compound due to a cyanide molecule stabilizing it. But don't worry about the presence of this molecule! Although cyanide is a poison, it is not present in high enough qualities to harm humans in any way.
Once inside the body, cyanocobalamin gets converted into both methylcobalamin and adenosylcobalamin. Your body might not be able to retain cyanocobalamin for long, but according to some studies, this form has a better absorption rate than methylcobalamin. Besides, cyanocobalamin supplements are more cost-effective than methyl B12, so they are in demand too.
Methylcobalamin is the type of vitamin B12 that is naturally occurring in food sources, especially animal products. Once cyanocobalamin is consumed, it can be converted to methylcobalamin or adenosylcobalamin. The absorption of either type can be affected by disease, genetics or even age. Cyanocobalamin has been shown to be the most stable type of vitamin B12.
Choose Between Pills, Liquids, and Sublingual
If you are not particular about the form, you can choose between tablets, capsules, or soft gels that are also available in various potencies. You can also find them in chewable forms, easier for older adults and children to consume.
However, sublingual and liquid forms of vitamin B12 are easy to consume and mostly do not contain artificial colors or sweeteners. The sublingual form is available as tablets or liquid. The vitamin easily enters the bloodstream as it melts fast under the tongue.
Liquids and sprays are easy to consume, especially for those having difficulty swallowing. They might be a bit more pricey, but the benefits you reap from these forms cannot be forgotten. Some organic liquid supplements also come in natural flavors for taste enhancement.
Look for Official Certifications (Especially if You're Vegan)
Being knowledgeable about the ingredients of nutrient supplements is important. Even if you are a meat-eater, consuming supplements filled with animal ingredients may or may not be a comfortable choice and you may prefer to choose a vegan supplement. Other things you can look for include non-GMO and cruelty-free as supplement makers cater to every diet nowadays!
Reading the supplement label will not just tell you the amount of vitamin B12 included, but can also give you additional information about and certifications the manufacturer has received. USP-certified labels can be found in authentically manufactured products. GMP compliance is another certification that you might find that assures the product was manufactured in an FDA-approved facility.
If you don’t find the GMP compliance label, then look for NSF and NPA labels; these are two organizations responsible for providing GMP certification to the manufacturer. Organic supplements also come with a variety of certifications specific to them. USDA-Organic is the most common of the certifications, besides the QAI-certified label.
You can also look for labels like 100 percent Organic, Organic, or Made with Organic Ingredients that indicate the product is Quality Assurance International or QAI certified. Products that are non-GMO, cruelty-free, or allergen-free will also have those mentioned in the product label, as per the norms.
How to Choose a Vitamin B12 Supplement - Buying Guide
Products | Image | Click to purchase | Key features | |
|---|---|---|---|---|
1 | Nature Made Vitamin Code Raw B12 Whole Food Supplement | | Currently unavailable | Best for Slow-Release and Maximum Absorption |
2 | Natrol Vitamin B12 Fast Dissolve Tablets | | Best for a High Potency Supplement | |
3 | Jarrow Formulas B-right Complex Supplement | | Best for a Variety of B Supplements | |
4 | Jarrow Formulas Methyl B-12 Lozenges | | Best Chewable, Low-Calorie and Low-Sugar Option | |
5 | MaryRuth Organics Vegan Vitamin D3+B12 Gummies | | Best for the Whole Family | |
6 | Vitafusion Organic B12 Gummy Vitamin | | Currently unavailable | Best Tasting Gummies |
7 | EZ Melts Vegan Sublingual Vitamins | | Best Choice for Quick-Dissolve Tablets | |
8 | Salt Lake Supplements Vitamin B12 Liquid Sublingual Drops | | Best for Fast Absorption | |
9 | MaryRuth Organics Organic Vitamin B12 Liquid | | Best Spray for Organic and Limited Diets | |
10 | Global Healing Center Organic Sublingual Liquid Vitamin B12 Drops | | Best Organic and All-Natural Choice |
Nature MadeVitamin Code Raw B12 Whole Food Supplement
Best for Slow-Release and Maximum Absorption
Pros:
- Slow-release formula
- Gluten-free
- No after-taste
- Well-known and respected supplement brand
Cons:
- Tablets too big for some reviewers
As you only need to take one tablet a day with these Nature Made supplements, one bottle will last for six months! The tablets have a slow-release formula to ensure maximum absorption of B12 by the body.
For reviewers that struggle with swallowing tablets, these were a little too big. However, most reviewers praise these tablets for being tasteless and not upsetting their stomachs. Many report feeling the benefits of additional energy after a period of taking these.
NatrolVitamin B12 Fast Dissolve Tablets
Best for a High Potency Supplement
Pros:
- High-strength tablets
- Suitable for vegetarians
- Fast dissolve tablets
- No artificial colors, flavors, or preservatives
Cons:
- Some ingredients are not suitable for all
- Potency may be too strong for some
Those with health conditions that affect their vitamin B12 absorption rates or those with severe vitamin B12 deficiency are good candidates for this supplement. It has a very high potency and is the strongest supplement on this list.
However, the tablets have a high concentration of the sugar substitute xylitol as well as wheat, making them unsuitable for those with gluten intolerances or digestive issues. Most reviewers agree that the tablets are easy to dissolve and have a pleasant taste.
Jarrow FormulasB-right Complex Supplement
Best for a Variety of B Supplements
Pros:
- Contains several B vitamins
- Low potency B12
- Vegan
- No odor or after-taste
Cons:
- Contains niacin
This B-complex form has 100 mcg of methylcobalamin along with a careful balance of other B vitamins. The formulation is odor-free despite the presence of choline bitartrate. The light potency makes it great to start supplementing B12.
Some reviewers complained of allergic reactions due to niacin flush, so avoid these tablets if you have this allergy! However, most reviewers that require various additional B vitamins in their diet praise these supplements for the many improvements to their energy levels and cognition.
Jarrow Formulas Methyl B-12 Lozenges
Best Chewable, Low-Calorie and Low-Sugar Option
Pros:
- Tablets dissolve in the mouth and can be chewed
- B12 is absorbed quickly
- Vegan and gluten-free
- Suitable for keto diets
Cons:
- Difficult to chew for some
- Includes xylitol
If swallowing tablets are difficult for you and you want to avoid the additional calories in gummies, these are a good option. They dissolve in the mouth and can be chewed, but be aware that they do contain xylitol. Although this is a healthier substitute for sugar and greatly reduces the sugar content, it can cause digestive issues in some people.
A lot of users experienced great benefits like increased energy, improved mood, and better sleep after being on this supplement. Some report noticing differences after only a few days and seeing results quickly in medical tests!
MaryRuth OrganicsVegan Vitamin D3+B12 Gummies
Best for the Whole Family
Pros:
- Includes B12 and D3
- Vegan and non-GMO
- Suitable for adults and children over two
Cons:
- Gummies can melt in transit or heat
Mary Ruth's Organic scores once again with these tasty gummies that both adults and kids would love to take. Its low B12 potency makes it suitable for children over two years old, but make sure you consult with a doctor before giving them to young children first.
The inclusion of vitamin D3 supports bone strength while 250 mg of methyl B12 supports nervous function and energy production. Many reviewers report that the gummies arrived melted and stuck together, so be careful if you live in warmer states!
VitafusionOrganic B12 Gummy Vitamin
Best Tasting Gummies
Pros:
- Easy to chew and swallow
- Tastes good
- Gluten and dairy-free
- No artificial flavors or synthetic dyes
Cons:
- Gummies can melt in transit or heat
- Not vegan
These B12 gummies have a delicious raspberry flavor and their quality and taste have been certified by ChefsBest. Many reviewers report that the gummies are tasty and easy to take, even for those with digestive issues.
Reviewers that live in warmer parts of the country found the gummies arrived melted into one large ball and couldn't be separated later, so be aware of this if you live in a state like Florida! Overall, the gummies are a tasty and effective way to supplement your B12 intake.
EZ MeltsVegan Sublingual Vitamins
Best Choice for Quick-Dissolve Tablets
Pros:
- Dissolve quickly under the tongue
- Tablets are smaller than many others
- Suitable for vegans
- No GMOs, gluten, sugar
Cons:
- Chalky texture is not liked by all
- Cherry flavor can taste artificial
This supplement is formulated to suit those needing some additional support with emotional balance and energy levels. The formula comes in fast-melting tablet form and most reviewers confirm that the tablets do indeed dissolve very quickly!
A few reviewers found that these tablets didn't work for them, however, many others report improvements in their energy levels and bloodwork. These tablets are suitable for vegans and also have no artificial flavors and colors.
Salt Lake SupplementsVitamin B12 Liquid Sublingual Drops
Best for Fast Absorption
Pros:
- Fast absorption
- Easy to use
- Suitable for vegans
- No dairy, gluten, or artificial colors and flavors
Cons:
- Some of the natural flavors have caused allergies
- Taste isn't liked by all
This sublingual spray is absorbed quickly and effectively. Several reviewers confirm that they feel the effects quickly and get a boost to their energy levels. Each bottle contains 60 servings of five sprays.
The ingredients and form of this supplement have changed over the last couple of years and some reviewers prefer the older version, but most are pleased with the effectiveness and absorption of this spray. They say it makes them feel better and is convenient to use.
MaryRuth OrganicsOrganic Vitamin B12 Liquid
Best Spray for Organic and Limited Diets
Pros:
- Easy to use
- Pleasant berry taste
- Vegan and non-GMO
- Dairy, gluten, wheat, and sugar-free
- Suitable for keto diets
Cons:
- Bottles can leak
- Reports of some side-effects
This organic form of sublingual methyl B12 is easy to use as it only requires two sprays into your mouth and you are done! Reviewers praise the berry taste and that there is no nasty aftertaste.
However, some users reported having side effects such as nausea and headache, so make sure you double-check the ingredients before purchase. The organic and natural properties of this supplement make it suitable for many diets and intolerances.
Global Healing CenterOrganic Sublingual Liquid Vitamin B12 Drops
Best Organic and All-Natural Choice
- Includes methylcobalamin and adenosylcobalamin
- Absorbed quickly
- Certified organic and non-GMO
- No gluten, dairy, or soy
Cons:
- May be too sweet for some
- Reports of some allergies
Purity and bioavailability make this blend of methylcobalamin and adenosylcobalamin unique. The potency is also high, so if you are a candidate who needs to supplement a lot, this choice is great. It's suitable for a wide variety of diets due to its natural ingredients and lack of additives.
However, some reviewers do report allergies and that the glycerin levels are too high, making it taste too sweet. Overall, this liquid form of B12 is easy to take and highly effective, due to its mix of methylcobalamin and adenosylcobalamin, and is certified both organic and free of GMOs.
Frequently Asked Questions
Even though you may have decided on a vitamin B12 supplement to buy, you may still have some lingering questions. So, we asked Rachel to answer some frequently asked questions on the Internet about vitamin B12.
What is the best time to take vitamin B12?
"Vitamin B12 is a water-soluble vitamin, so it may be beneficial to take it first thing in the morning with a glass of water to maximize absorption. This is especially true if you are deficient.
Some studies have shown that vitamin B12 may interfere with sleep if you take it right before bed. However, it is safe to take vitamin B12 at any time of day," says Rachel.
Can vitamin B12 supplements cause constipation or diarrhea?
Rachel says, "Constipation and diarrhea are rare side effects of vitamin B12. These are more common with high doses like those used to treat deficiency. Taking a lower dose may help alleviate these symptoms. In this case, it may be more beneficial to take vitamin B12 supplements with food. As always, speak with your doctor if side effects occur."
How do I know if I'm deficient in vitamin B12?
According to Rachel, "Fatigue is a symptom of vitamin B12 deficiency. If someone who is deficient goes on to consume adequate vitamin B12, they may notice a difference. This is not because of excess energy but because it is slowly helping to resolve a symptom."
This article doesn't serve to act as a diagnosis for vitamin B12 deficiency in any form, nor is it wise to diagnose yourself. Always keep in mind that you should check with your physician to know if you need additional intake or before buying a supplement.
Looking for Other Remedies to Fill Your Nutritional Gaps?
While the nutritional gap associated with one vitamin or mineral can result in multiple health issues, your body might demand the need of other nutrition as well. Here are some of our recommendations to fill those gaps.
Top 5 Vitamin B12 Supplements
No. 1: Nature Made｜Vitamin Code Raw B12 Whole Food Supplement
No. 2: Natrol｜Vitamin B12 Fast Dissolve Tablets
No. 3: Jarrow Formulas｜B-right Complex Supplement
No. 4: Jarrow Formulas ｜Methyl B-12 Lozenges
No. 5: MaryRuth Organics｜Vegan Vitamin D3+B12 Gummies
View Full RankingThe descriptions of each product are referenced from content available on manufacturer, brand, and e-commerce sites.